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Prehospital Thrombolysis: A Manual from Berlin

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Is sonothrombolysis an effective stroke treatment?

Milija D Mijajlovic¹, Aleksandra M Pavlovic, Nadezda Covickovic-Sternic

¹Neurology Clinic, Clinical Center of Serbia, and School of Medicine, University of Belgrade, 6 Subotica Dr, 11000 Belgrade, Serbia. milijamijajlovic@yahoo.com

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

|June 28, 2013

Summary

Ultrasound-enhanced thrombolysis, or sonothrombolysis, shows promise for improving stroke treatment by aiding clot lysis. Further research is needed to confirm its efficacy, safety, and optimal use in acute ischemic stroke.

Keywords:

acute ischemic stroke efficacy mechanisms of action safety sonothrombolysis

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Last Updated: May 10, 2026

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

Neurology
Biomedical Engineering
Cardiovascular Research

Background:

Acute ischemic stroke treatment focuses on improving recanalization and clinical outcomes.
Sonothrombolysis, using ultrasound to enhance clot breakdown, is an emerging therapeutic strategy.
The exact mechanisms of ultrasound's effect on thrombolysis are still under investigation, but nonthermal mechanical effects are suspected.

Purpose of the Study:

To explore the potential of ultrasound-enhanced thrombolysis as a novel treatment for acute ischemic stroke.
To evaluate the effectiveness of sonothrombolysis in promoting clot lysis, with or without microbubbles.
To assess the feasibility of using ultrasound for clot dissolution in stroke patients.

Main Methods:

Review of current research on ultrasound applications in thrombolysis.
Analysis of studies investigating the effects of ultrasound on clot lysis.
Examination of preliminary data on sonothrombolysis in ischemic stroke models.

Main Results:

Ultrasound, with or without microbubbles, demonstrates potential for enhancing clot lysis in ischemic stroke.
Evidence suggests ultrasound may facilitate clot breakdown even without the use of thrombolytic drugs.
Nonthermal mechanical effects of ultrasound are hypothesized to be key to its thrombolytic enhancement.

Conclusions:

Sonothrombolysis presents a promising avenue for acute ischemic stroke treatment.
Further clinical validation is required to establish the efficacy, safety, and technical parameters of sonothrombolysis.
More research is needed to fully elucidate the mechanisms and optimize the application of ultrasound in stroke therapy.