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Two cases of pilomatrix carcinoma
H Miyahara1, S Imayama, T Hashizume
1Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
The Journal of Dermatology
|May 1, 1990
Summary
Pilomatrix carcinoma, a rare skin cancer, requires aggressive treatment. Early diagnosis is crucial, as initial stages may mimic benign pilomatricoma but show concerning cellular atypia and mitotic activity.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Pilomatrix carcinoma is a rare malignant adnexal skin neoplasm.
- Distinguishing early pilomatrix carcinoma from benign pilomatricoma can be challenging.
Observation:
- Two cases of pilomatrix carcinoma are presented.
- The first case required extensive treatment including surgery, radiation, and chemotherapy due to recurrence.
- The second case demonstrated features of pilomatricoma centrally with invasive basaloid tumor cells peripherally.
Findings:
- Recurrent pilomatrix carcinoma exhibited definitive malignant characteristics clinically and histopathologically.
- Early-stage pilomatrix carcinoma presented with irregular nests of atypical basaloid cells and frequent mitoses.
Implications:
- Aggressive multimodal therapy may be necessary for advanced pilomatrix carcinoma.
- Histopathological evaluation for cellular atypia and mitotic activity is critical for early diagnosis of pilomatrix carcinoma.