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Recombinant human coxsackievirus B3 from children with acute myocarditis in China

Zhiqiang Wu1, Jiang Du, Ting Zhang

  • 1MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Journal of Clinical Microbiology
|June 28, 2013
PubMed

Insights

Recombination events were identified in two human coxsackievirus B3 strains linked to severe myocarditis in newborns and children. This finding is crucial for understanding coxsackievirus B3 evolution and disease.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Coxsackievirus B3 (CVB3) is a significant cause of viral myocarditis.
  • Hospital-acquired infections pose a threat to vulnerable populations, especially newborns.
  • Understanding viral evolution is key to controlling outbreaks.

Purpose of the Study:

  • To investigate the genetic characteristics of coxsackievirus B3 strains associated with severe myocarditis.
  • To identify potential recombination events in human CVB3 strains.

Main Methods:

  • Viral isolation from clinical samples.
  • Genetic sequencing of coxsackievirus B3 strains.
  • Bioinformatic analysis to detect recombination.

Main Results:

  • Recombination events were detected in two distinct human CVB3 strains: Beijing0811 and SD2012CHN.
  • Strain Beijing0811 was isolated from newborns with hospital-acquired acute myocarditis.
  • Strain SD2012CHN was isolated from children with hand, foot, and mouth disease and acute myocarditis.

Conclusions:

  • Recombination may play a role in the emergence of virulent coxsackievirus B3 strains.
  • These findings highlight the importance of genetic surveillance for CVB3.
  • Further research is needed to elucidate the functional impact of recombination on CVB3 pathogenicity.

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