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Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal

K Datta1, P Rhee, E Byrnes

  • 1Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Journal of Clinical Microbiology
|June 28, 2013
PubMed

Insights

Isavuconazole shows effectiveness against challenging fungal infections. This extended-spectrum triazole demonstrates higher activity against resistant molds like Aspergillus lentulus and Neosartorya udagawae, and Cryptococcus gattii.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Triazoles are crucial antifungal agents.
  • Emerging fungal pathogens pose treatment challenges.
  • Reduced susceptibility to existing azoles is a growing concern.

Purpose of the Study:

  • To evaluate the in vitro activity of isavuconazole.
  • To assess isavuconazole's efficacy against specific resistant fungal isolates.
  • To compare isavuconazole's activity with other azoles.

Main Methods:

  • In vitro susceptibility testing.
  • Utilized clinical isolates of Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii VGII.
  • Minimum Inhibitory Concentration (MIC) determination.

Main Results:

  • Isavuconazole demonstrated broad-spectrum in vitro activity.
  • Higher susceptibility was observed for Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii VGII to isavuconazole compared to other azoles.
  • These specific isolates exhibited reduced susceptibility to several conventional azoles.

Conclusions:

  • Isavuconazole is a promising antifungal agent.
  • It shows significant in vitro activity against azole-resistant fungal pathogens.
  • Isavuconazole may offer a valuable therapeutic option for infections caused by these challenging fungi.

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