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Updated: May 10, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Development and reliability of a correction factor for family-reported medication adherence: pediatric inflammatory

Yelena P Wu1, Ahna L H Pai, Wendy N Gray

  • 1Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self-Management, MLC-7039, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

Journal of Pediatric Psychology
|June 28, 2013
PubMed

Insights

Parental reports of medication adherence in children with inflammatory bowel disease (IBD) can be improved. New methods can correct subjective reports for better adherence assessment and improved treatment outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Health Services Research

Background:

  • Accurate medication adherence assessment is crucial for managing pediatric inflammatory bowel disease (IBD).
  • Parental subjective reports are commonly used but may overestimate adherence.
  • Electronic monitoring (EM) provides objective adherence data.

Purpose of the Study:

  • To evaluate the accuracy of parent-reported medication adherence in children with IBD.
  • To present and validate methods for correcting parent-reported adherence data.
  • To improve the reliability of adherence assessment in pediatric chronic illness management.

Main Methods:

  • 40 children with IBD underwent electronic monitoring (EM) for medication adherence.
  • Parents provided subjective adherence reports.
  • Receiver operating characteristic (ROC) analyses identified optimal cut-points for detecting non-adherence.
  • Two methods were applied to derive correction factors for parent reports.

Main Results:

  • Parental reports significantly correlated with EM adherence but were consistently higher.
  • A 90% adherence cut-point demonstrated the highest sensitivity and specificity.
  • Both derived correction factors effectively adjusted parent-reported adherence towards EM levels.

Conclusions:

  • Empirically derived correction factors can significantly enhance the accuracy of parent-reported medication adherence.
  • Improved adherence assessment has implications for self-management interventions.
  • Accurate adherence data can inform clinical prescribing and enhance medication safety in pediatric IBD.
Abstract

Keywords:
compliancemeasurementmedication-takingnonadherenceself-management

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