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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 10, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Ghrelin and bone.

Patric J D Delhanty1, Bram C J van der Eerden, Johannes P T M van Leeuwen

  • 1Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Biofactors (Oxford, England)
|June 28, 2013
PubMed
Summary
This summary is machine-generated.

Ghrelin, a stomach hormone, influences appetite and energy balance. This review explores ghrelin

Keywords:
boneghrelinleptinnutritionosteoblast

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Homeostasis

Background:

  • Ghrelin is a gut-derived peptide hormone primarily known for its orexigenic effects and role in energy homeostasis.
  • Bone remodeling is an energy-intensive process tightly linked to systemic energy metabolism.
  • Existing evidence suggests ghrelin influences bone cell function and interacts with the growth hormone (GH)-insulin-like growth factor axis.

Purpose of the Study:

  • To review the multifaceted role of ghrelin in modulating bone cell function.
  • To elucidate the integrative mechanisms by which ghrelin couples bone metabolism with energy homeostasis.

Main Methods:

  • Literature review of studies investigating ghrelin's effects on bone metabolism.
  • Analysis of research on the interplay between ghrelin, leptin, and energy balance in bone remodeling.

Main Results:

  • Ghrelin directly impacts osteoblast differentiation and function.
  • Ghrelin interacts with leptin to influence bone structure, establishing a novel link between bone and energy metabolism.
  • Ghrelin's regulation by metabolic status highlights its role in integrating systemic energy cues with skeletal health.

Conclusions:

  • Ghrelin is a key mediator connecting energy metabolism with bone remodeling.
  • Understanding ghrelin's role offers new insights into therapeutic strategies for metabolic and bone disorders.