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Is the ross procedure a suitable choice for aortic valve replacement in children with rheumatic aortic valve disease?
Bahaaldin Alsoufi1, Cedric Manlhiot, Bahaa Fadel
1King Faisal Heart Institute, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Insights
The Ross procedure offers excellent survival for children with rheumatic fever, but aortic regurgitation necessitates frequent autograft reoperation. Improved patient selection and surgical techniques can reduce reoperation rates.
Area of Science:
- Pediatric Cardiac Surgery
- Aortic Valve Replacement
- Rheumatic Heart Disease
Background:
- The Ross procedure is a preferred aortic valve replacement in pediatric patients.
- Concerns exist regarding late autograft reoperation due to dilatation and regurgitation after the Ross procedure.
- Suitability of the Ross procedure in children with rheumatic fever requires investigation.
Purpose of the Study:
- To evaluate the long-term outcomes of the Ross procedure in children with rheumatic fever.
- To determine the incidence and risk factors for autograft reoperation and death.
- To assess freedom from aortic regurgitation and need for homograft or any cardiac reoperation.
Main Methods:
- Retrospective review of medical records for 104 children with rheumatic fever who underwent the Ross procedure (1991-2004).
- Application of competing risks methodology to analyze time-related prevalence of reoperation and death.
- Identification of associated risk factors for adverse outcomes.
Main Results:
- Ten-year survival was excellent (1% mortality), but 32% required autograft reoperation.
- Freedom from moderate or severe aortic regurgitation at 10 years was 63%.
- Freedom from autograft reoperation was lower for regurgitation (65%) than stenosis (90%); earlier surgery year and lack of annular stabilization were risk factors.
Conclusions:
- The Ross procedure in children with rheumatic fever demonstrates excellent survival but is challenged by significant aortic regurgitation and high rates of autograft reoperation.
- Preoperative regurgitation, concomitant surgery, and earlier surgical era are identified risk factors for autograft reoperation.
- Enhanced patient selection and refined surgical techniques, including root and sinotubular stabilization, are crucial for improving long-term outcomes and reducing reoperation rates.
Background:
Ross procedure is the aortic valve replacement of choice in children. Nonetheless, late autograft reoperation for dilatation and/or regurgitation is concerning. We examine whether Ross procedure is suitable in children with rheumatic fever.
Methods:
Medical records of 104 children with rheumatic fever who underwent Ross procedure were reviewed (1991-2004). Competing risks methodology determined time-related prevalence and associated factors for two mutually exclusive end states: autograft reoperation and death prior to subsequent reoperation.
Results:
Mean age was 13.8 ± 2.7, 83 (80%) were males. Hemodynamic dysfunction was primarily regurgitation (n = 92, 88%) and stenosis/mixed (n = 12, 12%). Competing risks analysis showed that in ten years after the Ross procedure, 1% of patients died, 32% underwent autograft reoperation, and 67% were alive and free from reoperation. Ten-year freedom from aortic regurgitation greater than or equal to moderate was 63%. Ten-year freedom from autograft reoperation was 65% for regurgitation versus 90% for stenosis/mixed disease. Risk factors for autograft reoperation were earlier surgery year (PE: 0.26 ± 0.06 per year; P < .001), additional surgery (PE: 0.82 ± 0.39, P = .04), no annular stabilization (PE: 1.21 ± 0.61, P = .05). Ten-year freedom from homograft replacement was 83%. Risk factors were fresh homografts (PE: 1.36 ± 0.71; P = .06) and aortic homografts (PE: 1.15 ± 0.59; P = .05). Ten-year freedom from any cardiac reoperation was 53%. Concomitant cardiac surgery was risk factor (PE: 1.37 ± 0.47; P = .004).
Conclusions:
Ross procedure in children with rheumatic fever is associated with excellent survival but results are plagued by aortic regurgitation and frequent autograft reoperation. Risk factors include preoperative regurgitation, concomitant surgery, dilated annulus, and earlier surgery era. Better patient selection in later era has mitigated autograft reoperation risk. Continued, improved candidate selection, along with modifications in autograft implantation and root/sinotubular stabilization techniques, may further decrease late autograft failure.
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