Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...

Heart Valves

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

Heart Failure I: Introduction

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ultra-Thin Sirolimus-Eluting Versus Everolimus-Eluting Stents in Diabetic Multivessel Coronary Artery Disease Patients: The TUXEDO-2 Trial.

Journal of the American College of Cardiology·2026

Same author

Altered expression of KCNQ1OT1 and ZEB1-AS1 lncRNAs in autism spectrum disorder: A case-control study.

Molecular biology reports·2026

Same author

Iatrogenic Bile Duct Injury in 2025: Real World Causes, Referral Patterns, and Reconstruction Outcomes From a Tertiary Care Centre in a Sub-himalayan Region.

Cureus·2026

Same author

RETRACTED: Role of Dom Community in Cremation Rituals: A Socio-Cultural Study of Funeral Grounds in Varanasi.

Omega·2026

Same author

A survey of studies on blood lead concentrations and its health outcomes in Nepal: A review.

Environmental toxicology and pharmacology·2026

Same author

Tacrolimus for Dry Eye Disease: Translational Insights from Animal Models and Clinical Studies into Molecular Pathways and Anti-Inflammatory Mechanisms.

Current pharmaceutical design·2026

Search research articles

Related Experiment Video

Updated: May 10, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Hematologic alterations in patients with functionally univentricular hearts.

Zeena Makhija¹, Rajesh Sharma

¹Division of Congenital Cardiac Surgery, Fortis Escorts Heart Research Institute, New Delhi, India.

World Journal for Pediatric & Congenital Heart Surgery

|June 28, 2013

Summary

Patients with univentricular hearts face bleeding risks before surgery and a clotting risk after, impacting Fontan circulation outcomes. Anticoagulation benefits after univentricular repair remain debated.

Keywords:

Fontan coagulation single ventricle

More Related Videos

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

Published on: May 13, 2016

Related Experiment Videos

Last Updated: May 10, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

Published on: May 13, 2016

Area of Science:

Cardiology
Hematology
Pediatric Surgery

Background:

Patients with univentricular hearts have complex coagulation profiles.
Preoperative bleeding risks transition to postoperative prothrombotic states after surgical repair.

Purpose of the Study:

To examine the shift in coagulation status from bleeding to prothrombotic states in patients with univentricular hearts.
To evaluate the implications of this prothrombotic state on thromboembolic events post-Fontan circulation establishment.

Main Methods:

Review of coagulation profiles in patients undergoing univentricular repair.
Analysis of thromboembolic event incidence following Fontan circulation.

Main Results:

Coagulation factor deficiencies initially cause bleeding risks.
Postoperative states reveal a prothrombotic predisposition, increasing thromboembolic event risk.
These events contribute to significant morbidity in Fontan patients.

Conclusions:

The prothrombotic shift post-univentricular repair is a critical factor in Fontan circulation morbidity.
The efficacy and necessity of anticoagulation in this population require further investigation.