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Updated: May 10, 2026
Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
Published on: December 21, 2016
[Effects of CdTe QDs on chromosome aberration of CHL cells in vitro]
Guangyun Xie1, Quankai Wang, Anna Wang
1Institute for Ocuupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing, China. guangyunxie@163.com
Objective:
To observed the chromosome oberration of CHL cells induced by CdTe QDs.
Methods:
The chromosome oberration test of Chinese hamster lung (CHL) cell was conducted in CdTe QDs at the concentrations of 1.6, 3.2, 6.3, 12.6 and 25.2 microl/ml, under the metabolic (+S9) and non-metabolic (-S9) activation systems.
Results:
The chromosome oberration rate of 12.6 and 25.2 microl/ml CdTe QDs groups were significantly higher than the control groups (P<0.01) Under the condition of metabolic activation. Main types of chromosomal aberrations was broken, fragmented and exchange.
Conclusion:
It was suggested that CdTe QDs could induce the effects of chromosome oberration under the metabolic activation systems (+S9).
