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Signaling pathway switch in breast cancer

Arnaud Guille1, Max Chaffanet, Daniel Birnbaum

  • 1Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, "Equipe labellisée Ligue Contre le Cancer", UMR1068 Inserm, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Université, 27 bd, Leï Roure, BP 30059, Marseille 13273, France. daniel.birnbaum@inserm.fr.

Cancer Cell International
|June 29, 2013
PubMed
Summary

Next-generation sequencing reveals key breast cancer pathways. The PI3 kinase/AKT pathway is activated while the JUN/MAPK pathway is repressed, impacting tumor-initiating cells.

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