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Related Concept Videos

Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...

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Related Experiment Video

Updated: May 10, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

Are we counting mitoses correctly?

Nuri Yigit1, Armagan Gunal, Zafer Kucukodaci

  • 1Gulhane Military Medical Academy and School of Medicine, Department of Pathology, Ankara, Turkey.

Annals of Diagnostic Pathology
|June 29, 2013
PubMed
Summary
This summary is machine-generated.

Pathologic evaluation of tumors relies on counting mitotic figures. Modern microscopes have larger fields of view, necessitating adjustments to traditional mitosis counting methods for accurate tumor grading and prognosis.

Keywords:
Counting mitosisMitotic activity index (MAI)Ocular magnificationVisual field area

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

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Published on: September 20, 2019

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Area of Science:

  • Pathology
  • Oncology
  • Histopathology

Background:

  • Mitotic figure counting is crucial for tumor evaluation, grading, and prognosis.
  • Current standards for mitosis counting are based on older microscopy with narrower fields of view.
  • Tumor invasion fronts are typically preferred for mitosis assessment.

Purpose of the Study:

  • To address the need for updated mitosis counting criteria.
  • To ensure compatibility with modern, high-power field microscopes.
  • To refine prognostic and diagnostic accuracy in tumor pathology.

Main Methods:

  • Reviewing established protocols for mitotic count standardization.
  • Comparing field of view differences between older and modern microscopes.
  • Proposing necessary corrections for current mitosis counting practices.

Main Results:

  • Older microscopes had significantly narrower fields of view compared to current state-of-the-art microscopes.
  • A discrepancy exists between historical and current microscopic field sizes for mitosis counting.
  • Corrections are required to standardize mitosis counts across different microscope generations.

Conclusions:

  • Mitotic count standardization requires adaptation to modern microscopy.
  • Adjusted criteria will enhance the reliability of tumor grading and prognosis.
  • Accurate mitotic counting is vital for effective patient management in oncology.