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Updated: May 10, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Prostate cancer chemoprevention
Gurdarshan S Sandhu1, Kenneth G Nepple, Youssef S Tanagho
1Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Seminars in Oncology
|June 29, 2013
Summary
Prostate cancer chemoprevention research, focusing on nutrients and 5 alpha-reductase inhibitors (5ARIs), shows limited benefits. While 5ARIs show some promise, concerns about high-grade disease and lack of FDA approval remain.
Area of Science:
- Oncology
- Preventive Medicine
Background:
- Prostate cancer is a significant cause of male morbidity and mortality.
- Treatment complications necessitate effective chemoprevention strategies.
- Current research focuses on nutrients and 5 alpha-reductase inhibitors (5ARIs).
Purpose of the Study:
- To review the efficacy of chemopreventive agents for prostate cancer.
- To evaluate the role of nutrients and 5ARIs in prostate cancer prevention.
Main Methods:
- Review of major randomized controlled trials, including SELECT, PCPT, and REDUCE.
- Analysis of findings related to selenium, vitamin E, and 5ARIs.
Main Results:
- The SELECT trial found no benefit from selenium or vitamin E for prostate cancer prevention.
- PCPT and REDUCE trials suggested a role for 5ARIs but raised concerns about increased high-grade disease.
- The US Food and Drug Administration (FDA) has not approved 5ARIs for chemoprevention.
Conclusions:
- Conclusive evidence for nutrient or vitamin chemoprevention is lacking.
- The role of 5ARIs in prostate cancer chemoprevention requires further clarification.
- Ongoing research is crucial for developing effective prostate cancer prevention strategies.
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