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Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
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Ascorbyl palmitate interaction with phospholipid monolayers: electrostatic and rheological preponderancy

Milagro Mottola1, Natalia Wilke, Luciano Benedini

  • 1Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional del Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina.

Biochimica Et Biophysica Acta
|June 29, 2013
PubMed
Summary

Ascorbyl palmitate (ASC16) interacts complexly with model membranes, penetrating phospholipid monolayers and influencing membrane fluidity. Its adsorption and penetration depend on pH and membrane properties, impacting its pharmacological function.

Keywords:
1,2-dimyristoyl-sn-glycero-3-phospho-(1′-rac-glycerol)1,2-dimyristoyl-sn-glycero-3-phosphocholineASC(16)BAMBrewster angle microscopyCPCholCs(−1)DLSDMPCDMPGGibbs monolayersLCLELiquid-condensed domainsMMASAXSVitamin C derivativesascorbyl palmitatecholesterolcollapsed phasecompressibility modulusdynamic light scatteringliquid-condensedliquid-expandedmean molecular areasmall angle X-ray scatteringsurface potentialsurface pressureΔVπ

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