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Biochemical changes in erythrocyte membrane in type 2 diabetes mellitus
1Department of Biochemistry, SSR Medical College, Mauritius.
Objective:
This study aims to establish a link between the lipid composition of red blood cell membrane and serum to aid in the early diagnosis and treatment of patients with type 2 diabetes mellitus.
Materials And Methods:
Diabetic subjects with and without dyslipidemia were selected along with healthy control subjects. Biochemical changes in serum and erythrocyte membrane were compared in study groups.
Results:
The lipid composition of membrane was significantly altered with increased cholesterol:Phospholipid ratio and decreased Na + K + -ATPase of membrane upon comparison with control subjects.
Conclusion:
Increased hyperglycemia with altered serum lipid composition in diabetes mellitus causes glycation of membrane enzymes this along with oxidative stress leads to decrease in activity of Na + K + -ATPase and other changes in erythrocyte membrane. Significant findings of the study: As the lipid level increases there is increased lipid peroxidation and the membrane composition gets altered.
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