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Related Concept Videos

Introduction to Actin01:26

Introduction to Actin

Actin is a highly conserved cytoskeletal protein found abundantly in eukaryotic cells. It constitutes 10% weight of the total cellular protein in muscle cells, while in non-muscle cells, it is lower and makes up around 1–5 percent of the total cell protein. Actin found in the unicellular amoebae and complex multicellular animals is around 80% similar, demonstrating their conservation over a billion years of evolution.  Actin coding genes are conserved within species and across different species.
Golgi Apparatus01:49

Golgi Apparatus

As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.

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Related Experiment Video

Updated: May 10, 2026

In Vitro Polymerization of F-actin on Early Endosomes
12:15

In Vitro Polymerization of F-actin on Early Endosomes

Published on: August 28, 2017

Actin acting at the Golgi.

Gustavo Egea1, Carla Serra-Peinado, Laia Salcedo-Sicilia

  • 1Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, C/Casanova, 143, 08036, Barcelona, Spain. gegea@ub.edu

Histochemistry and Cell Biology
|June 29, 2013
PubMed
Summary
This summary is machine-generated.

Actin cytoskeleton proteins organize the Golgi apparatus structure and influence membrane trafficking. This review details actin

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Last Updated: May 10, 2026

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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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Aip1p Dynamics Are Altered by the R256H Mutation in Actin

Published on: July 30, 2014

Area of Science:

  • Cell Biology
  • Cytoskeleton Dynamics
  • Membrane Trafficking

Background:

  • The actin cytoskeleton is crucial for cellular processes, including membrane trafficking.
  • The Golgi apparatus relies on structural organization for its functions.

Purpose of the Study:

  • To review the role of actin and its associated proteins in Golgi apparatus organization.
  • To illustrate actin's involvement in Golgi-derived membrane trafficking.

Main Methods:

  • Literature review of studies using various cellular models.
  • Analysis of actin and binding protein functions in Golgi structure and trafficking.

Main Results:

  • Actin and its regulatory proteins are integral to Golgi structural organization.
  • These proteins facilitate sorting, biogenesis, and movement of Golgi-derived transport carriers.

Conclusions:

  • Actin and its co-workers play a significant role in Golgi apparatus structure and function.
  • Understanding these interactions is key to deciphering membrane trafficking pathways.