Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.

Acta neuropathologica communications·2026
Same author

Parametric optimization of transcranial focused ultrasound neuromodulation of the periaqueductal grey for blood pressure reduction.

Brain stimulation·2026
Same author

Focused ultrasound in pediatric neuro-oncology: Current applications and future directions.

Neuro-oncology advances·2026
Same author

Anti-focus driving signals to mitigate bone heating during focused ultrasound ablation of uterine fibroids with phased arrays.

Physics in medicine and biology·2026
Same author

A numerical analysis of anti-focus driving to improve focal quality in transvertebral focused ultrasound.

The Journal of the Acoustical Society of America·2026
Same author

Focused Ultrasound Treatment of Vitreous Hemorrhage in an In Vivo Rabbit Model.

Ophthalmology science·2026

Related Experiment Video

Updated: May 10, 2026

Pipeline for Planning and Execution of Transcranial Ultrasound Neuromodulation Experiments in Humans
07:52

Pipeline for Planning and Execution of Transcranial Ultrasound Neuromodulation Experiments in Humans

Published on: June 28, 2024

Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration

Ryan M Jones1, Meaghan A O'Reilly, Kullervo Hynynen

  • 1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada. rmjones@sri.utoronto.ca

Physics in Medicine and Biology
|June 29, 2013
PubMed
Summary

Passive acoustic mapping through the skull is feasible using sparse hemispherical arrays and CT-based aberration corrections. This technique shows promise for monitoring transcranial focused ultrasound treatments.

More Related Videos

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning
08:41

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning

Published on: July 14, 2020

Related Experiment Videos

Last Updated: May 10, 2026

Pipeline for Planning and Execution of Transcranial Ultrasound Neuromodulation Experiments in Humans
07:52

Pipeline for Planning and Execution of Transcranial Ultrasound Neuromodulation Experiments in Humans

Published on: June 28, 2024

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning
08:41

Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning

Published on: July 14, 2020

Area of Science:

  • Medical Imaging
  • Acoustics
  • Biomedical Engineering

Background:

  • Transcranial focused ultrasound (FUS) treatments require real-time monitoring, especially for non-thermal applications.
  • Current monitoring techniques are limited for cavitation-mediated FUS applications like blood-brain barrier disruption.

Purpose of the Study:

  • To investigate the feasibility of transcranial passive acoustic mapping using sparse hemispherical arrays.
  • To assess the impact of CT-based aberration corrections on image quality.
  • To evaluate the potential for monitoring FUS treatments.

Main Methods:

  • Developed a multi-layered ray acoustic model incorporating CT-derived skull morphology.
  • Implemented a passive beamforming algorithm with skull-specific aberration corrections.
  • Simulated acoustic source fields through digitized human skulls and compared reconstructions to water-path controls.

Main Results:

  • Passive acoustic mapping through intact skulls was demonstrated using sparse hemispherical arrays.
  • Trans-skull reconstructions closely matched water-path control images.
  • Image quality was analyzed based on beamwidths, sidelobe ratio, and SNR, considering various system and skull parameters.

Conclusions:

  • Sparse hemispherical arrays with CT-based aberration corrections enable feasible transcranial passive acoustic mapping.
  • This technique can potentially monitor transcranial focused ultrasound (FUS) treatments, including cavitation-mediated applications.
  • It offers a potential real-time monitoring solution where none currently exists.