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Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Skeletal muscle stem cells.

Methods in molecular biology (Clifton, N.J.)·2013

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Updated: May 10, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

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Published on: October 3, 2014

Cellular cardiomyoplasty: its past, present, and future.

Elizabeth K Lamb1, Grace W Kao, Race L Kao

  • 1Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 29, 2013
PubMed
Summary

Cellular cardiomyoplasty uses stem cells for heart repair, offering mild functional improvements in heart failure patients. Further research is needed to clarify mechanisms and optimize this innovative cell therapy.

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Published on: September 22, 2014

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Therapy

Background:

  • Cellular cardiomyoplasty, a cell therapy for myocardial regeneration, emerged in 1989 as an alternative to heart transplantation.
  • It aims to improve cardiac function and mitigate heart failure using stem cells or progenitor cells.

Purpose of the Study:

  • To review stem cells utilized in cellular cardiomyoplasty.
  • To summarize clinical outcomes of the procedure.
  • To identify areas for future optimization and research.

Main Methods:

  • Review of experimental and clinical studies on cellular cardiomyoplasty.
  • Analysis of reported cardiac function, metabolism, and perfusion improvements.
  • Examination of safety, feasibility, and efficacy data.

Main Results:

  • Studies generally show mild but incomplete improvements in cardiac function, metabolism, and perfusion.
  • Safety, feasibility, and efficacy are documented, but beneficial mechanisms remain unclear.
  • Various stem cells have been investigated for this application.

Conclusions:

  • Cellular cardiomyoplasty is an established innovative therapy for damaged myocardium.
  • Optimization and a clearer understanding of underlying mechanisms are crucial for advancing the procedure.
  • Further studies are needed to enhance clinical outcomes in heart failure treatment.