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Related Experiment Video

Updated: May 10, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Malignant bladder pheochromocytoma with SDHB genetic mutation.

M Maeda¹, Y Funahashi, M Katoh

¹Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Aktuelle Urologie

|June 29, 2013

Summary

A rare case of malignant pheochromocytoma in the bladder, a type of neuroendocrine tumor, was successfully treated with radical cystectomy. Genetic analysis identified a hereditary syndrome, crucial for understanding and managing this rare cancer.

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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

Urology
Oncology
Genetics

Background:

Pheochromocytomas are rare neuroendocrine tumors typically arising in the adrenal medulla.
Malignant pheochromocytomas can occur outside the adrenal glands, presenting diagnostic and therapeutic challenges.

Observation:

A 30-year-old male presented with micturition pain due to a bladder submucosal tumor with obturator lymph node metastasis.
Initial transurethral resection confirmed invasive malignant pheochromocytoma.

Findings:

Radical cystectomy, neobladder reconstruction, and lymph node dissection were performed.
Genetic analysis revealed succinate dehydrogenase B (SDHB)-associated hereditary pheochromocytoma/paraganglioma syndrome.
The patient showed no evidence of recurrence 10 months post-surgery.

Implications:

This case highlights the importance of considering pheochromocytoma in bladder tumors, especially with lymph node involvement.
SDHB-associated hereditary syndromes require thorough genetic evaluation and long-term surveillance.
Multidisciplinary management, including surgery and genetic counseling, is critical for favorable outcomes in rare malignancies.