[Prognostic value of interleukin-6 in various biological environments in generalized peritonitis]

The author analyzed the results of surgical treatment of 60 patients with generalized peritonitis (GP). The level of interleukin-6 in blood, serum, urine and peritoneal exudates were followed up and the diagnostic significance of interleukin was comparatively studied. All patients were treated by conventional intensive postoperative therapy, without immune correction. The severity of GP was determined by Mannheim peritoneal index (MPI): 17 patients had MPI, 20 patients had MPI II-23 and MPI III. The study revealed that the degree of the changes of IL-6 in blood, urine and peritoneal exudates depended on the severity of patients according to MPI. An analysis of the data suggests that the comparative study of IL-6 in peritoneal exudates, blood, urine during the postoperative period in patients with GP is one of the objective criteria for the assessment of the immune system. Increasing the rates of peritoneal exudates in the postoperative period shows a continuation of the systemic inflammatory response.