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Related Experiment Video

Updated: May 10, 2026

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

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Plasmodium nesting: remaking the erythrocyte from the inside out.

Justin A Boddey¹, Alan F Cowman

¹Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; email: boddey@wehi.edu.au , cowman@wehi.edu.au.

Annual Review of Microbiology

|July 2, 2013

Summary

Plasmodium parasites remodel red blood cells (erythrocytes) during malaria infection. This review details how exported proteins alter host cells for parasite survival and immune evasion.

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Published on: January 3, 2011

Area of Science:

* Parasitology and Cell Biology
* Molecular and Cellular Mechanisms of Disease

Background:

* Malaria is caused by Plasmodium parasites, which infect erythrocytes (red blood cells).
* Erythrocytes are terminally differentiated cells lacking essential organelles like the nucleus, posing unique challenges for intracellular parasites.
* Plasmodium parasites extensively modify host erythrocytes to support their survival and replication.

Purpose of the Study:

* To review recent research on erythrocyte remodeling by Plasmodium parasites.
* To elucidate the mechanisms of protein export utilized by the parasite.
* To identify key exported proteins, their functions, and subcellular localization within the host erythrocyte.

Main Methods:

* Review of current scientific literature on Plasmodium-erythrocyte interactions.
* Analysis of studies detailing protein export pathways.
* Examination of research identifying and characterizing exported parasite proteins.

Main Results:

* Plasmodium parasites export hundreds of proteins into erythrocytes shortly after invasion.
* These exported proteins reconfigure the host cell's machinery for nutrient uptake, protein trafficking, and immune evasion.
* Key exported proteins play critical roles in establishing a suitable intracellular environment for parasite development.

Conclusions:

* Erythrocyte remodeling is a crucial strategy for Plasmodium survival and pathogenesis.
* Understanding protein export mechanisms and the functions of exported proteins is vital for developing malaria control strategies.
* Further research into these molecular interactions can reveal novel therapeutic targets.