Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Karyotyping01:17

Karyotyping

Overview
Karyotyping01:17

Karyotyping

Overview
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mycophenolate-Induced Colitis Complicated by Cytomegalovirus in an Immunocompromised Patient With Interstitial Lung Disease.

ACG case reports journal·2026
Same author

Destaining hematoxylin and eosin stains and restaining for immunohistochemistry has diagnostic value for cytology samples.

CytoJournal·2026
Same author

Oxygen Sensor-Guided Fine Needle Biopsy Studies of Human Cancer Xenografts in Mice.

bioRxiv : the preprint server for biology·2024
Same author

Corrigendum to "False-Negative Pap Tests in Women with Biopsy-Proven Invasive Endocervical Adenocarcinoma/Adenocarcinoma In Situ: A Retrospective Analysis with Assessment of Inter-Observer Agreement" Journal of the American Society of Cytopathology 2021;11:3-12.

Journal of the American Society of Cytopathology·2022
Same author

Liquid-based rapid onsite evaluation of endobronchial ultrasound cytologies.

Journal of the American Society of Cytopathology·2022
Same author

Fluorescence Polarization Imaging of Methylene Blue Facilitates Quantitative Detection of Thyroid Cancer in Single Cells.

Cancers·2022

Related Experiment Video

Updated: May 10, 2026

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Five top stories in cytopathology.

Andrew H Fischer1, Cynthia C Benedict, Mojgan Amrikachi

  • 1Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA. Andrew.Fischer@umassmemorial.org

Archives of Pathology & Laboratory Medicine
|July 2, 2013
PubMed
Summary

Classical cytomorphology remains crucial for diagnosis and understanding cancer biology. Advances in molecular diagnostics and imaging techniques are reshaping cytopathology, presenting both opportunities and challenges for the field.

More Related Videos

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

Related Experiment Videos

Last Updated: May 10, 2026

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

Area of Science:

  • Cytopathology
  • Oncology
  • Medical Diagnostics

Background:

  • Cytology diagnoses traditionally rely on morphology, with limited recent changes in criteria.
  • The field is currently influenced by advancements in imaging, sample acquisition, molecular diagnostics, therapeutics, and regulatory factors.

Purpose of the Study:

  • To assess the enduring significance of classical morphology in cytopathology.
  • To identify the evolving scope and shaping factors within the field of cytology.

Main Methods:

  • A comprehensive literature review was conducted.

Main Results:

  • Classical cytomorphology is essential for diagnosis and cancer biology insights.
  • New imaging and endoscopy techniques are increasingly substituting surgical biopsies with cytology samples.
  • Molecularly targeted therapies present new roles and challenges for cytology.

Conclusions:

  • Molecular tests can complement, not replace, morphology in thyroid fine-needle aspirations.
  • Interventional cytopathology, including ultrasound-guided fine-needle aspiration, is an emerging valuable subspecialty.
  • Active participation in clinical trials is vital for cytopathologists to demonstrate cytology's cost-effectiveness.