Enantioselective total syntheses of pygmaeocins B and C
Akiko Obase1, Akihito Kageyama, Yuki Manabe
1Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima, 770-8505, Japan.
Organic Letters
|July 2, 2013
Abstract:
The first enantioselective total syntheses of pygmaeocins B and C have been accomplished using an efficient and highly diastereoselective intramolecular Heck cyclization for the construction of a quaternary stereogenic center and the functionalized A-ring of the natural products as the key step.
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