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Heart-type fatty acid-binding protein as a potential biomarker of acute carbon monoxide poisoning

Ali Kemal Erenler1, Turker Yardan, Ahmet Baydin

  • 1Hitit University, Çorum Education and Research Hospital, Department of Emergency Medicine, Çorum, Turkey.

The American Journal of Emergency Medicine
|July 2, 2013
PubMed

Insights

Serum heart-type fatty acid-binding protein (H-FABP) is a potential biomarker for assessing carbon monoxide (CO) poisoning severity and guiding hyperbaric oxygen (HBO) therapy selection.

Area of Science:

  • Biochemistry
  • Toxicology
  • Emergency Medicine

Background:

  • Carbon monoxide (CO) poisoning is a significant public health concern.
  • Accurate evaluation of CO poisoning severity is crucial for appropriate patient management.
  • Novel biomarkers are needed to improve diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the diagnostic and prognostic role of serum heart-type fatty acid-binding protein (H-FABP) in acute carbon monoxide (CO) poisoning.
  • To assess the correlation between H-FABP levels and clinical severity.
  • To evaluate H-FABP as a predictor for hyperbaric oxygen (HBO) therapy.

Main Methods:

  • A study involving 40 acute CO poisoning patients and 15 healthy controls.
  • Serum H-FABP levels were measured on admission and at 6, 12, and 18 hours post-admission.
  • Patients were stratified by clinical severity (mild, moderate, severe) and treatment (HBO vs. normobaric oxygen).

Main Results:

  • Serum H-FABP levels were elevated in CO poisoning patients compared to controls.
  • H-FABP levels negatively correlated with Glasgow Coma Scale scores.
  • Higher H-FABP levels were observed in severe cases and in patients receiving HBO therapy.
  • A cutoff of 1.5 ng/mL for H-FABP indicated a need for HBO treatment with 85.7% sensitivity and 69.7% specificity.

Conclusions:

  • Serum H-FABP shows promise as a biomarker for evaluating CO poisoning severity.
  • H-FABP may aid in selecting patients who would benefit from HBO therapy.
  • Serial H-FABP measurements reflect the dynamic changes in CO poisoning.
Abstract

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