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Updated: May 10, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

[Clozapine-induced parotitis: a case study].

C Gouzien¹, A Valiamé², D Misdrahi³

¹Centre de référence régional des pathologies anxieuses et de la dépression, centre expert dépression résistante fondation fondamental, Bordeaux cedex, France; Université Bordeaux Segalen, 146, rue Léo-Saignat, 33077 Bordeaux cedex, France; Pôle de psychiatrie adulte 347, centre hospitalier Charles-Perrens, 121, rue de la Béchade, 33076 Bordeaux cedex, France.

|July 2, 2013

Summary

Clozapine, a crucial antipsychotic, can rarely cause parotitis, an inflammation of the salivary glands. This case highlights the importance of recognizing this rare side effect, especially after dose adjustments, to ensure proper patient management.

Keywords:

Clozapine Parotidite Parotitis Schizophrenia Schizophrénie Sialorrhea Sialorrhée

Related Experiment Videos

Last Updated: May 10, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Area of Science:

Pharmacology
Psychiatry
Toxicology

Background:

Clozapine is a primary treatment for treatment-resistant schizophrenia.
Common side effects include sedation, weight gain, and hypersalivation.
Clozapine-induced parotitis is a rare but significant adverse event.

Observation:

A patient with refractory schizoaffective disorder developed parotitis after a clozapine dose increase.
Symptoms included auricular pain, odynophagia, and parotid gland swelling.
Infectious causes were ruled out, and clozapine was implicated.

Findings:

The patient experienced increased hypersalivation with higher clozapine dosage.
Parotitis resolved after reducing the clozapine dose.
Both immune and inflammatory mechanisms are proposed for clozapine-induced parotitis.

Implications:

This case underscores the need for clinicians to consider clozapine-induced parotitis in patients with unexplained parotid swelling.
Awareness of this complication can lead to timely diagnosis and management.
Further research into the pathophysiology of clozapine-induced parotitis is warranted.