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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
06:09

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Published on: July 18, 2017

Impact of renal dysfunction in cirrhotic patients with bacterial infections other than spontaneous bacterial

Tsung-Hsing Hung1, Chu-Lin Chou, Te-Chao Fang

  • 1Division of Gastroenterology, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi; School of Medicine, Tzu Chi University.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|July 2, 2013
PubMed
Abstract

Insights

Renal function impairment (RFI) significantly increases mortality in cirrhotic patients with bacterial infections, excluding spontaneous bacterial peritonitis (SBP). Acute renal failure (ARF) presents a particularly poor prognosis, highlighting the need for closer monitoring and intervention.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Cirrhotic patients are susceptible to bacterial infections.
  • The impact of renal dysfunction on outcomes in cirrhotic patients with non-spontaneous bacterial peritonitis (SBP) infections is not well understood.

Purpose of the Study:

  • To investigate the association between renal function impairment (RFI) and mortality in cirrhotic patients diagnosed with bacterial infections other than SBP.

Main Methods:

  • A population-based cohort study analyzed data from 7134 cirrhotic patients with non-SBP bacterial infections from Taiwan's National Health Insurance Database (2004).
  • Patients were categorized based on the presence and severity of renal dysfunction, including acute renal failure (ARF) and end-stage renal disease (ESRD).

Main Results:

  • 8.1% of patients had RFI, with 223 cases of ARF and 141 cases of ESRD.
  • RFI was associated with significantly higher 30-day, 1-year, and 3-year mortality rates compared to patients without RFI.
  • ARF demonstrated a particularly high adjusted hazard ratio for mortality across all time points compared to both non-RFI and ESRD groups.

Conclusions:

  • Renal function impairment (RFI), particularly acute renal failure (ARF), is an independent predictor of poor prognosis in cirrhotic patients with non-SBP bacterial infections.
  • These findings underscore the critical role of renal status in determining outcomes for this vulnerable patient population.
Keywords:
acute renal failurebacterial infectionscirrhosisend-stage renal diseaserenal dysfunction

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