Related Experiment Video
Updated: May 10, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Cyclotide biosynthesis
1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. d.craik@imb.uq.edu.au
Abstract:
Cyclotides are bioactive macrocyclic peptides from plants that are characterized by their exceptional stability and potential applications as protein engineering or drug design frameworks. Their stability arises from their unique cyclic cystine knot structure, which combines a head-to-tail cyclic peptide backbone with three conserved disulfide bonds having a knotted topology. Cyclotides are ribosomally synthesized by plants and expressed in a wide range of tissues, including leaves, flowers, stems and roots. Here we describe recent studies that have examined the biosynthesis of cyclotides and in particular the mechanism associated with post-translational backbone cyclization.
More Related Videos
09:08From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
08:46Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
Published on: July 26, 2018
Related Concept Videos
Biosynthesis of Nucleic Acids
Amino Acid Biosynthetic Pathways
Biosynthesis of Polysaccharides
Biosynthesis in Bacteria
Cycloaddition Reactions: Overview
Thermal and Photochemical Electrocyclic Reactions: Overview