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Updated: May 10, 2026

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
Published on: September 28, 2016
Calcineurin-dependent ion channel regulation in heart
Yanggan Wang1, Samvit Tandan2, Joseph A Hill3
1Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Pediatrics, Emory University, Atlanta, GA, USA.
Abstract:
Calcineurin, a serine-threonine-specific, Ca(2+)-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field.
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