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Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

Influenza virus A(H3N2) strain isolated from cerebrospinal fluid from a patient presenting myelopathy post infectious

T M Paiva1, G Theotonio, R S Paulino

  • 1Núcleo de Doenças Respiratórias, Instituto Adolfo Lutz, São Paulo, SP, Brazil. tterezinha@uol.com.br

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|July 2, 2013
PubMed
Abstract

Insights

Influenza A(H3N2) virus caused myelopathy in a student after an influenza-like illness. This finding highlights the potential for neurological complications from influenza infections.

Area of Science:

  • Neurology
  • Virology
  • Epidemiology

Background:

  • Neurological complications, including severe outcomes and death, are known risks associated with influenza infections during epidemics.
  • Investigating the specific viral cause of myelopathy following influenza-like illness is crucial for understanding disease pathogenesis.

Observation:

  • A 19-year-old male student presented with myelopathy after experiencing influenza-like symptoms.
  • Cerebrospinal fluid (CSF) was collected for etiological investigation.

Findings:

  • Influenza A(H3N2) virus was successfully isolated from the CSF using cell culture techniques.
  • Electron microscopy confirmed the presence of virus particles, and phylogenetic analysis linked the strain to A/Perth/16/2009-like viruses.

Implications:

  • This study confirms Influenza A(H3N2) as the causative agent of myelopathy in this case.
  • The findings underscore the importance of considering influenza virus in cases of neurological illness post-influenza-like syndrome.
  • The predominance of A/Perth/16/2009-like (H3N2) strains in Brazil during the 2010 season is noted.
Keywords:
Cerebrospinal fluidInfluenza A(H3N2) strainLaboratory diagnosisReal time RT-PCRVirus sequencing

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