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Related Experiment Video

Updated: May 10, 2026

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
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Published on: March 11, 2021

The double burden.

Daniel Faurholt-Jepsen1

  • 1Department of Human Nutrition, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark. daniel@faurholt-jepsen.dk

Danish Medical Journal
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Diabetes significantly increases tuberculosis risk and mortality in Tanzania. This study highlights the urgent need to address the dual burden of these diseases in Africa, impacting treatment outcomes and survival.

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Area of Science:

  • Global Health
  • Infectious Diseases
  • Endocrinology

Background:

  • Urbanization and lifestyle changes are increasing chronic diseases, including diabetes, in tuberculosis-burdened populations.
  • Diabetes is strongly associated with increased susceptibility to active tuberculosis.
  • Tuberculosis may impair glucose metabolism, potentially leading to diabetes.

Purpose of the Study:

  • To assess the role of diabetes in tuberculosis risk, clinical manifestations, treatment outcomes, and survival in Tanzania.
  • To investigate the prevalence of diabetes among tuberculosis patients and controls in Mwanza City, Tanzania.

Main Methods:

  • A study involving 1,250 newly diagnosed pulmonary tuberculosis patients and 350 neighborhood controls in Mwanza City, Tanzania.
  • Participants underwent diabetes and HIV testing, anthropometric, clinical, and paraclinical measurements.
  • Follow-up at 2, 5 months for treatment outcomes and 1 year for survival status.

Main Results:

  • Prevalence of impaired glucose and diabetes was significantly higher in tuberculosis patients (38% impaired, 17% diabetes) than controls (21% impaired, 9% diabetes).
  • Diabetes was associated with a fourfold increased odds of tuberculosis, independent of HIV co-infection.
  • Diabetes co-morbidity led to slower weight and hemoglobin recovery and a fourfold higher mortality rate during initial tuberculosis treatment.

Conclusions:

  • The co-existence of tuberculosis and diabetes presents a major public health challenge in Africa.
  • Increasing diabetes incidence may impede tuberculosis control efforts and potentially lead to a resurgence in tuberculosis cases.
  • Future research should focus on improved diagnostics for tuberculosis patients with diabetes and understanding disease/drug interactions.