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Updated: May 10, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Role of KLF5 in hormonal signaling and breast cancer development
Rong Liu1, Jin-Tang Dong, Ceshi Chen
1Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
Abstract:
Steroid hormones, including ovarian steroid hormones progesterone and estrogen and androgen, play vital roles in the development of normal mammary gland and breast cancer via their receptors. How these hormones regulate these physiological and pathological processes remains to be elucidated. Krüppel-like factor 5 (KLF5) is a transcription factor playing significant roles in breast carcinogenesis, whose expression has been shown to be regulated by hormones. In this review, the relationships among hormonal signaling, KLF5, and breast cancer are summarized and discussed.
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