Related Experiment Video
Updated: May 10, 2026

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids
Published on: April 5, 2024
[Radiosensitization induced by vemurafenib]
A Ducassou1, I David, M Delannes
1Département de Radiothérapie, Institut Claudius-Regaud, 20-24 Rue du Pont-St-Pierre, 31052 Toulouse cedex, France. ducassou.anne@claudiusregaud.fr
Abstract:
The recent use of vemurafenib, a specific inhibitor of BRAF, has led to a significant improvement in disease-free survival and overall survival of patients treated for a BRAF-mutated metastatic melanoma. This new class of drugs is not devoid of side effects, including skin effects. In particular, its association with concomitant radiotherapy should be taken into consideration, vemurafenib appearing to be radiosensitizer. The radiation oncologist must be aware of this potential toxicity, which is not uncommon in clinical practice.
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