[Distribution of an antimicrobial agent in oral tissues of rabbit. Cefuroxime axetil]

The distribution of cefuroxime (CXM) was examined in NZW rabbits after oral administration at a dose of 20 mg/kg of cefuroxime axetil. CXM was detected in blood, oral tissues (tongue, gingiva, parotid gland, submandibular gland, cervical lymph nodes and lower jaw bone), liver and kidney. The results were analyzed through pharmacokinetic calculation. Ratio of pharmacokinetic parameters in the tissues and those in the serum (free) were as follows: Cmax: 0.26 to 0.62, AUC: 0.70 to 1.53, MRT: 2.6 to 3.0, VRT: 7.7 to 12.2.