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[Malignant lymphoma associated with Addison's disease].

H Shigemi1, S Murakami, N Oku

  • 1Second Department of Medicine, Kyoto Prefectural University of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|April 1, 1990
PubMed
Summary

This case study details a 62-year-old man with Non-Hodgkin's lymphoma presenting with adrenal tumors and Addison's disease. Despite treatment, the patient experienced relapse and ultimately died from multiple organ failure.

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Area of Science:

  • Oncology
  • Endocrinology
  • Pathology

Background:

  • Malignant lymphoma can present with extranodal involvement, including adrenal glands.
  • Adrenal insufficiency may occur secondary to lymphoma infiltration or treatment.

Observation:

  • A 62-year-old male presented with fatigue, hyperpigmentation, and lymphadenopathy.
  • Radiology revealed massive adrenal and lung tumors.
  • Endocrinological tests indicated adrenal insufficiency (Addison's disease) and elevated ACTH levels.

Findings:

  • A lymph node biopsy confirmed Non-Hodgkin's lymphoma, diffuse large cell type.
  • Radiotherapy and chemotherapy (VEPA, PEP-VP) initially reduced adrenal tumor size.
  • Adrenal function did not recover despite treatment response.

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Implications:

  • This case highlights the complex interplay between lymphoma and adrenal function.
  • It underscores the challenges in managing adrenal insufficiency secondary to malignancy.
  • Early recognition and multidisciplinary management are crucial for such complex cases.