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Antibacterial effect of mango (Mangifera indica Linn.) leaf extract against antibiotic sensitive and multi-drug

Abdul Hannan1, Samra Asghar, Tahir Naeem

  • 1Department of Microbiology, University of Health Sciences, Lahore, Pakistan.

Pakistan Journal of Pharmaceutical Sciences
|July 2, 2013
PubMed

Insights

Mango leaves show significant potential in combating typhoid fever. Acetone mango leaf extract (AMLE) demonstrated antimicrobial activity against both multi-drug resistant (MDR) and sensitive Salmonella typhi strains.

Area of Science:

  • Phytochemistry
  • Microbiology
  • Pharmacology

Background:

  • Alternative herbal medicine offers natural compounds with potential antibiotic properties.
  • Multi-drug resistant (MDR) Salmonella typhi poses a significant challenge in treating typhoid fever.
  • Mango leaves possess reported medicinal effects, including antimicrobial properties.

Purpose of the Study:

  • To investigate the anti-typhoid efficacy of acetone mango leaf extract (AMLE).
  • To evaluate AMLE against both antibiotic-sensitive and MDR Salmonella typhi isolates.

Main Methods:

  • Preparation of acetone mango leaf extract (AMLE).
  • Antibacterial activity assessed using agar well diffusion.
  • Minimum Inhibitory Concentration (MIC) determined by agar dilution technique.
  • Standard quality control strains (Staphylococcus aureus, Salmonella typhimurium) used.

Main Results:

  • AMLE showed an inhibitory zone of 18±1.5mm against MDR and sensitive S. typhi isolates.
  • Inhibitory zones against quality control strains were 20±1.5mm.
  • The Minimum Inhibitory Concentration (MIC) of AMLE ranged from 10-50 mg/ml.

Conclusions:

  • Acetone mango leaf extract exhibits significant inhibitory effects against Salmonella typhi.
  • Mango leaves represent a potential natural source for developing anti-typhoid agents.
  • Further research into AMLE's phytoconstituents and mechanisms is warranted.

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