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Updated: May 10, 2026

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Published on: June 30, 2016
Pleiotropic effects of GacA on Pseudomonas fluorescens Pf0-1 in vitro and in soil
Sarah C Seaton1, Mark W Silby, Stuart B Levy
1Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Abstract:
Pseudomonas species can exhibit phenotypic variation resulting from gacS or gacA mutation. P. fluorescens Pf0-1 is a gacA mutant and exhibits pleiotropic changes following the introduction of a functional allele. GacA enhances biofilm development while reducing dissemination in soil, suggesting that alternative Gac phenotypes enable Pseudomonas sp. to exploit varied environments.
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