Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting static ice storage in clinical lung transplantation: Direct and continuous temperature monitoring of donor lungs followed by mathematical modeling.

JHLT open·2026
Same author

Author's Response to letter to the editor "Commentary on: the effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide" (JBMM-D-26-00062).

Journal of bone and mineral metabolism·2026
Same author

Factors influencing long-term outcomes in lung transplantation: effective monitoring and comprehensive intervention.

Current opinion in pulmonary medicine·2026
Same author

The effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide.

Journal of bone and mineral metabolism·2026
Same author

Long-term postoperative outcomes of post-axial polydactyly of the foot with an emphasis on collateral ligament reconstruction.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association·2025
Same author

Does the Lateral Cubital Retinaculum Isolation or Repair in the Triceps Tongue Approach Affect Elbow Extension? A Cadaver Study.

Clinical orthopaedics and related research·2025

Related Experiment Video

Updated: May 10, 2026

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

[The changes in bone geometric parameters by medication].

Junichi Takada1, Kousuke Iba, Toshihiko Yamashita

  • 1Dept. of Orthopaedic Surgery, Sapporo Medical University, Japan.

Clinical Calcium
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Certain osteoporosis medications significantly improve bone strength more than bone density, particularly in the hip region. These findings offer insights into optimizing fracture prevention strategies through targeted bone geometry improvements.

More Related Videos

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
04:20

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Published on: September 1, 2023

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Related Experiment Videos

Last Updated: May 10, 2026

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
04:20

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Published on: September 1, 2023

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Area of Science:

  • Orthopedics and Bone Metabolism
  • Pharmacology
  • Biomechanical Engineering

Context:

  • Osteoporosis treatment aims to reduce fracture risk by improving bone strength.
  • Hip structure analysis (HSA) provides detailed geometric bone parameters.
  • Understanding medication effects on bone geometry is crucial for treatment selection.

Purpose:

  • To review and compare the effects of various osteoporosis medications on bone geometric parameters, specifically hip structure analysis (HSA).
  • To evaluate how different drugs influence bone strength indices like section modulus compared to bone mineral density.

Summary:

  • Raloxifene, bisphosphonates (alendronate, risedronate, minodronate), and denosumab enhanced section modulus (a measure of bending strength) more effectively than bone mineral density, with greater effects in the intertrochanteric region compared to the femoral neck.
  • Teriparatide (20μg/day) showed a different pattern, with similar improvements in section modulus and bone mineral density, and no greater effect in the intertrochanter than the femoral neck.
  • Femoral shaft parameters showed less significant changes with these medications, except for a similar tendency to change as the proximal femur with bisphosphonates, raloxifene, and denosumab.

Impact:

  • These findings highlight that certain medications improve bone strength (section modulus) more than bone density, suggesting a more direct impact on fracture resistance.
  • The differential effects of medications on various hip regions (intertrochanter vs. femoral neck) can inform personalized treatment strategies for osteoporosis.
  • This review provides valuable data for clinicians and researchers in selecting therapies that optimize biomechanical bone properties for fracture prevention.