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Related Experiment Video

Updated: May 10, 2026

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

Age-related changes in brain support cells: Implications for stroke severity.

Farida Sohrabji¹, Shameena Bake, Danielle K Lewis

¹Department of Neuroscience and Experimental Therapeutics, Women's Health in Neuroscience Program, Texas A&M HSC College of Medicine, Bryan, TX 77807, United States. Sohrabji@medicine.tamhsc.edu

Neurochemistry International

|July 2, 2013

Summary

Aging brains experience more severe strokes due to decreased support cell function. This review explores how astrocytes and endothelial cells contribute to stroke severity in older individuals, including sex-based differences.

Keywords:

Aging Astrocytes Endothelial cells Hormones Stroke

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Last Updated: May 10, 2026

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

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Published on: November 14, 2020

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Area of Science:

Neuroscience
Gerontology
Pathology

Background:

Stroke is a major cause of adult disability and mortality, particularly in the elderly.
Aged animals exhibit more severe strokes than younger animals, with a loss of neuroprotective effects seen in young females.
Understanding age-related stroke severity is crucial for developing effective treatments.

Purpose of the Study:

To review the hypothesis that reduced functional capacity of critical support cells contributes to stroke severity in the aging brain.
To examine the roles of astrocytes and endothelial cells in age-related stroke.
To discuss sex differences in stroke severity, focusing on estrogen's effects.

Main Methods:

Review of preclinical literature on aging, stroke, astrocytes, endothelial cells, and sex differences.
Analysis of studies on middle-aged acyclic females and estrogen's impact.

Main Results:

The aging brain is more susceptible to severe infarction.
Reduced functional capacity of astrocytes and endothelial cells may increase stroke severity in older individuals.
Sex differences in neuroprotection observed in young animals are absent in older females.

Conclusions:

Aging compromises the brain's support systems, leading to worse stroke outcomes.
Astrocytes and endothelial cells are key players in age-related stroke severity.
Further research into sex-specific mechanisms, including estrogen's role, is warranted for targeted stroke therapies.