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Related Experiment Video

Updated: May 10, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Longitudinal changes in left ventricular stiffness: a community-based study.

Barry A Borlaug¹, Margaret M Redfield, Vojtech Melenovsky

¹Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.

Circulation. Heart Failure

|July 2, 2013

Summary

This summary is machine-generated.

Left ventricular (LV) stiffness increases with age in humans, even when arterial stiffness and blood pressure are reduced. This age-related stiffening affects both systolic and diastolic function, particularly in women, and may require new therapeutic targets.

Keywords:

aging arterial stiffness heart failure hemodynamics ventricular function

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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

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Last Updated: May 10, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

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Published on: December 2, 2014

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Area of Science:

Cardiology
Gerontology
Biomedical Engineering

Background:

Cross-sectional studies indicate age-related increases in left ventricular (LV) and arterial elastance.
Longitudinal data on human aging of LV and arterial elastance are limited.
The relationship between age-related LV stiffening and arterial stiffening remains unclear.

Purpose of the Study:

To longitudinally assess changes in LV and arterial elastance in humans over time.
To determine if age-related LV stiffening is a consequence of arterial stiffening or an independent process.

Main Methods:

Utilized comprehensive echo-Doppler cardiography in 1402 community-based subjects.
Paired data from 788 subjects were analyzed over a 4-year follow-up period.
Measured LV end-systolic elastance (Ees), end-diastolic elastance (Eed), and effective arterial elastance.

Main Results:

Despite a 4-year decrease in blood pressure, arterial elastance, and LV mass, LV systolic elastance (Ees) increased by 14% and diastolic elastance (Eed) by 8%.
Increases in Eed were more pronounced in women.
Age-related increases in Ees and Eed correlated with body weight changes and were similar in subjects with or without cardiovascular disease.

Conclusions:

LV systolic and diastolic stiffness progressively increase in humans over time, independent of arterial load reduction.
Therapies targeting load-independent ventricular stiffening may be crucial for preventing age-associated cardiovascular diseases.
Findings highlight the need for interventions beyond blood pressure control to address age-related cardiac stiffening.