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Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

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Related Experiment Video

Updated: May 10, 2026

Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier

Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier

Published on: January 12, 2024

Stem cells behind the barrier.

Michael Cangkrama¹, Stephen B Ting, Charbel Darido

¹Epidermal Development Laboratory, Department of Medicine, Central Clinical School, Alfred Hospital and Monash University, Prahran VIC 3004, Australia. charbel.darido@monash.edu.

International Journal of Molecular Sciences

|July 2, 2013

Summary

Epidermal stem cell differentiation is crucial for skin barrier function but poorly understood. This review covers advances in stem cell differentiation mechanisms and their role in maintaining skin health.

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Published on: March 2, 2020

Area of Science:

Dermatology
Stem Cell Biology
Molecular Biology

Background:

Adult skin relies on epidermal stem cells for lifelong renewal and barrier formation.
Stem cell progeny differentiate to create the protective epidermal barrier.
While barrier repair is understood, stem cell differentiation pathways are less clear.

Purpose of the Study:

To review current understanding of epidermal stem and progenitor cell differentiation.
To explore mechanisms regulating stem cell differentiation.
To identify new relationships for skin barrier maintenance.

Main Methods:

Literature review of current research on epidermal stem cell differentiation.
Synthesis of findings on molecular mechanisms controlling stem cell fate.
Exploration of the link between differentiation and skin barrier function.

Main Results:

Key regulators include asymmetric cell divisions, microRNAs, chromatin remodeling, and differentiation factors.
Disruption of stem/progenitor cell balance leads to skin diseases.
Advances highlight complex molecular networks governing stem cell differentiation.

Conclusions:

Understanding stem cell differentiation is vital for skin health.
Further research into these mechanisms can reveal new therapeutic targets.
This knowledge is essential for maintaining skin barrier integrity and function.