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Morphological characterization of systemic changes in KK-Ay mice as an animal model of type 2 diabetes

Takayasu Moroki1, Yutaka Yoshikawa, Katsuhiko Yoshizawa

  • 1Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan.

In Vivo (Athens, Greece)
|July 2, 2013
PubMed
Abstract

Insights

KK-Ay mice, a model for type 2 diabetes, show early hyperglycemic changes in systemic organs. These include islet cell hypertrophy, altered kidney structure, and fatty liver, impacting drug development for diabetes.

Area of Science:

  • * Metabolic research
  • * Animal models of diabetes

Background:

  • * KK-Ay mice are a widely used model for human type 2 diabetes mellitus.
  • * This model is crucial for evaluating new anti-diabetic medications.

Purpose of the Study:

  • * To investigate the systemic organ changes associated with the early hyperglycemic state in KK-Ay mice.
  • * To characterize the progression of diabetes-related pathologies in this model.

Main Methods:

  • * KK-Ay mice were studied at 5 weeks (non-hyperglycemic) and 10-14 weeks (hyperglycemic).
  • * Comparisons were made with age-matched C57BL/6J mice.

Main Results:

  • * Islet cell hypertrophy and increased islet area ratio observed in hyperglycemic KK-Ay mice.
  • * Elevated plasma insulin in 14-week-old mice.
  • * Kidney changes (mesangial matrix enlargement, increased glomerular area), fatty liver, and increased plasma cholesterol and triglycerides were noted.

Conclusions:

  • * Early hyperglycemia in KK-Ay mice is linked to systemic organ alterations.
  • * These findings highlight the utility of KK-Ay mice for understanding early diabetes pathogenesis.
Keywords:
DiabetesKK-Ay miceanimal modelkidneyliverpancreas

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