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Published on: September 12, 2019
Concomitant interferon-alpha and chemotherapy in hepatitis C and colorectal cancer: a case report
Ivan Gentile1, Alfonso De Stefano, Giusy Di Flumeri
1Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, Via S. Pansini 5, I-80131 Naples, Italy. ivan.gentile@unina.it
Abstract:
Hepatitis C virus (HCV) infection is one of the main causes of liver disease worldwide. Patients undergoing surgery are at risk of acquiring acute HCV infection and those undergoing surgical eradication of a neoplasia may be indicated for adjuvant treatment. Therefore, unlike chronic infection, these patients may simultaneously need antiviral therapy with interferon for acute hepatitis C and cytotoxic chemotherapy. To date, no data are available regarding the efficacy and tolerability of concomitant interferon treatment and antineoplastic chemotherapy in the setting of acute hepatitis C treatment. Here, we report the case of a 60-year-old man who developed acute hepatitis C after left hemicolectomy for an adenocarcinoma. He received concomitant antiviral treatment with interferon-α and adjuvant chemotherapy with capecitabine and oxaliplatin. Both treatments were well-tolerated and the patient completed the scheduled therapies. HCV infection was eradicated and the patient is free of neoplastic disease two years and 6 months after surgery.
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