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Updated: May 10, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
The contentious ontogeny of fibrosis in the kidney
1Division of Nephrology and Kidney Research Institute, University of Washington, Medical Centre, Seattle, Washington 98195, USA. nelsonpj@uw.edu
Abstract:
Arguably, no cell biology related to the loss of renal function is more debated than the ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing most of the excess extracellular matrix in diseased kidneys derive from epithelial cells versus pericytes resident within the kidney. Reich et al. now contend that circulating bone marrow-derived fibrocytes independent of monocyte lineages are an important source of fibrogenic cells recruited to the kidney following injury.
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