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Updated: May 10, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Müllerian anomalies and recurrent miscarriage
Mayumi Sugiura-Ogasawara1, Yasuhiko Ozaki, Nobuhiro Suzumori
1Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
Current Opinion in Obstetrics & Gynecology
|July 2, 2013
Summary
Congenital uterine anomalies affect 3.2-10.4% of women with recurrent miscarriages. Surgery
Area of Science:
- Reproductive Medicine
- Gynecology
- Obstetrics
Background:
- Congenital uterine anomalies are associated with recurrent miscarriages.
- Prevalence varies, with major anomalies (excluding arcuate uterus) found in 3.2-10.4% of women with recurrent miscarriages.
- Accurate diagnosis and classification are crucial for understanding reproductive outcomes.
Purpose of the Study:
- To review the prevalence of congenital uterine anomalies.
- To examine pregnancy outcomes in patients with these anomalies.
- To assess the impact of surgical correction on live birth rates.
Main Methods:
- Review of existing literature on uterine anomalies and pregnancy outcomes.
- Utilized hysterosalpingography and 2D ultrasound as initial screening tools.
- Referenced the American Fertility Society classification of Müllerian anomalies.
Main Results:
- A significant percentage of women with recurrent miscarriages have uterine anomalies.
- Live birth rates after surgical correction for bicornuate or septate uteri range from 35.1-65.9%.
- In the absence of surgery, cumulative live birth rates were comparable between women with anomalies and those with normal uteri (78.0% vs. 85.5%).
Conclusions:
- The effectiveness of surgical intervention in improving live birth rates for recurrent miscarriages remains uncertain.
- Further randomized controlled trials are needed to compare surgical and non-surgical management.
- Establishing whether surgery improves live birth rates requires more robust evidence.
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