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Is there association between acyl-ghrelin and inflammation in hemodialysis patients?

Amanda de Faria Barros1, Cristiane Moraes, Milena Barcza Stockler Pinto

  • 1Graduate Program on Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil. afariabarros@gmail.com

Jornal Brasileiro De Nefrologia
|July 2, 2013
PubMed

Insights

Chronic kidney disease patients on hemodialysis have low acyl-ghrelin levels, suggesting resistance to this appetite hormone. Inflammation markers were elevated, but not correlated with acyl-ghrelin levels.

Area of Science:

  • Nephrology
  • Endocrinology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is often associated with anorexia and inflammation.
  • The orexigenic hormone acyl-ghrelin plays a role in appetite regulation.
  • Understanding the interplay between inflammation and acyl-ghrelin in CKD patients on hemodialysis (HD) is crucial for managing nutritional status.

Purpose of the Study:

  • To investigate the association between plasma acyl-ghrelin levels and inflammatory markers in CKD patients undergoing hemodialysis.
  • To evaluate the relationship between acyl-ghrelin and nutritional status indicators like Body Mass Index (BMI).

Main Methods:

  • Thirty-six patients on a regular HD program were studied.
  • Plasma levels of acyl-ghrelin, TNF-α, IL-6, and CRP were measured using enzyme immunoassay.
  • Anthropometric parameters and dietary intake were assessed.

Main Results:

  • CKD patients exhibited elevated levels of inflammatory markers (IL-6, TNF-α, CRP) compared to normal values.
  • Plasma acyl-ghrelin levels were low in HD patients compared to healthy individuals.
  • A negative correlation was found between acyl-ghrelin and BMI (r = -0.38, p = 0.02), with lower acyl-ghrelin in patients with BMI > 25 kg/m².
  • No significant correlation was observed between acyl-ghrelin and the measured inflammatory markers.

Conclusions:

  • Hemodialysis patients demonstrate low acyl-ghrelin levels, indicating potential acyl-ghrelin resistance.
  • The study found no correlation between inflammation and acyl-ghrelin levels in this patient group.
  • These findings suggest that anorexia in CKD patients on HD may not be directly mediated by acyl-ghrelin in the context of inflammation.
Abstract

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