Related Experiment Video
Updated: May 10, 2026
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
Rhabdoid glioblastoma: a recently recognized subtype of glioblastoma
Shao-Ching Chen1, Diego Shih-Chieh Lin, Cheng-Chia Lee
1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 17F, No. 201, Shih-Pai Road, Sec. 2, Peitou, Taipei 11217, Taiwan, Republic of China.
Background:
Rhabdoid glioblastoma is a rare type of recently described malignant brain tumor. It is characterized by a glioblastoma associated with rhabdoid components.
Methods:
Here we report two cases of rhabdoid glioblastoma and a brief literature review. The first patient was a 19-year-old boy who initially presented with a foul-smelling odor and progressive right-side weakness. The second case was a 29-year-old male patient who presented only with a severe headache.
Results:
Both of these patients were young, and the disease progression was quick despite optimal treatment.
Conclusion:
The diagnosis of rhabdoid glioblastoma was confirmed after microscopic and immunohistochemical findings.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:24Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
01:14Rab Proteins
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...