The advances of electromigration techniques applied for alkaloid analysis

Area of Science:

• Analytical Chemistry
• Natural Products Chemistry

Background:

• Alkaloids, plant-derived natural products, possess diverse pharmacological activities.
• Their presence in food and medicine necessitates sensitive analytical methods.
• Electromigration techniques offer promising solutions for alkaloid analysis.

Purpose of the Study:

• To review developments in electromigration techniques for alkaloid analysis over the past 12 years.
• To cover key aspects including detection, preconcentration, and chiral separation.
• To examine applications in alkaloid determination and related fields.

Main Methods:

• Capillary Electrophoresis (CE)
• Microchip Electrophoresis (ME)
• On- and off-line preconcentration techniques
• Chiral separation methods

Main Results:

• Significant advancements in CE and ME for alkaloid analysis.
• Improved detection and preconcentration strategies for enhanced sensitivity.
• Successful chiral separations of alkaloid enantiomers.
• Applications in capillary electrochromatography and study of intermolecular interactions.

Conclusions:

• Electromigration techniques, particularly CE and ME, are powerful tools for alkaloid research.
• These methods provide sensitive and selective analysis for various applications.
• Continued development promises further insights into alkaloid chemistry and pharmacology.