Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Blood and Nerve Supply to the Bones

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recognition, treatment, and control of hypertension in the Danish population-based Lolland-Falster Health Study.

European journal of public health·2026

Same author

Surgeons' perspectives on patient-specific 3D-printed temporal bone models: What do we need?

International journal of pediatric otorhinolaryngology·2026

Same author

Mitigating Teclistamab Toxicity: Prophylactic Tocilizumab and Timing of Immunoglobulin Replacement Therapy in a Nationwide Cohort.

American journal of hematology·2026

Same author

Effects of a Low-PRAL Modified New Nordic Renal Diet on Acid-Base Status in Patients With Stage 4-5 Chronic Kidney Disease and Chronic Metabolic Acidosis.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2026

Same author

Management and treatment of chronic kidney disease in the Danish Lolland-Falster Health Study: focus on renoprotection and cardiovascular disease prevention.

Clinical kidney journal·2025

Same author

High prevalence of unrecognized chronic kidney disease in the Lolland-Falster Health Study: a population-based study in a rural provincial area of Denmark.

European journal of public health·2025

Search research articles

Related Experiment Video

Updated: May 10, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

How to exhaust your bone marrow.

Louise Salomo¹, Morten Salomo, Steven A W Andersen

¹Department of Nephrology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. Louise@salomo.dk

BMJ Case Reports

|July 2, 2013

Summary

Excessive physical activity and insufficient nutrition led to gelatinous bone marrow transformation in a healthy man. This rare condition, typically seen in severe illness, highlights the risks of overtraining and inadequate dietary intake.

More Related Videos

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Published on: May 19, 2019

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Related Experiment Videos

Last Updated: May 10, 2026

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Published on: May 19, 2019

Osteoclast Derivation from Mouse Bone Marrow

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Area of Science:

Sports Medicine
Hematology
Nutrition Science

Background:

Overtraining syndrome can impact physiological markers, necessitating a deeper understanding of its hematological consequences.
Gelatinous bone marrow transformation (GBMT) is a rare finding typically associated with critical illness or severe malnutrition.

Observation:

A 32-year-old male presented with edema and weight gain, later developing moderate pancytopenia.
Despite a normal Body Mass Index (BMI) and high energy/protein intake, the patient engaged in excessive physical activity.
Bone marrow biopsy revealed gelatinous bone marrow transformation.

Findings:

The patient's condition was attributed to overtraining syndrome combined with relatively insufficient nutrition.
This case suggests that extreme physical exertion, even with adequate BMI, can induce GBMT.

Implications:

Highlights the potential for overtraining and nutritional imbalances to cause significant hematological changes.
Suggests GBMT may occur in contexts beyond critical illness or severe malnutrition.
Underscores the importance of balanced nutrition and appropriate training loads in athletes and physically active individuals.