Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A functional psychosis precipitated by quinidine.

A G Johnson1, R O Day, W A Seldon

  • 1Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst, NSW.

The Medical Journal of Australia
|July 2, 1990
PubMed
Summary

Quinidine, a medication for heart rhythm issues, may trigger psychosis and cognitive decline in some patients. Stopping the drug can rapidly reverse these symptoms, suggesting a link between quinidine and functional psychosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SULPHAMEZATHINE IN GONORRHOEA IN THE MALE: A REPORT ON FIFTY CASES OF GONOCOCCAL URETHRITIS.

The British journal of venereal diseases·2011
Same author

Anuria due to Sulphapyridine Calculi.

British medical journal·2010
Same author

Simulated laparoscopic cholecystectomy.

Annals of the Royal College of Surgeons of England·2009
Same author

Non-Newtonian bile flow in elastic cystic duct: one- and three-dimensional modeling.

Annals of biomedical engineering·2008
Same author

One-dimensional models of the human biliary system.

Journal of biomechanical engineering·2007
Same author

A randomized, double-blind, placebo-controlled, parallel-group study to assess the efficacy and safety of dual ACE/NEP inhibitor GW660511X in mild-to-moderate hypertensive patients.

Journal of human hypertension·2006

Area of Science:

  • Neuroscience
  • Cardiology
  • Psychiatry

Background:

  • A 62-year-old male patient presented with progressive cognitive deterioration and paranoid features.
  • The patient had a history of supraventricular tachyarrhythmia treated with quinidine since 1974.

Observation:

  • Clinical examination revealed patchy cognitive deficits without focal neurological signs.
  • Standard investigations yielded unremarkable results.
  • Discontinuation of quinidine led to rapid and complete resolution of psychiatric and cognitive symptoms within days.

Findings:

  • The patient experienced a recurrence of paranoid and depressive symptoms months later, which responded to pimozide and dothiepin.
  • These episodes are likely a recurring functional psychosis precipitated or exacerbated by quinidine.

Related Experiment Videos

  • This highlights a potentially unrecognized complication of quinidine therapy.

    • Implications:

    • Quinidine therapy should be evaluated in patients presenting with dementia or functional psychosis.
    • Clinicians should consider quinidine as a potential contributing factor to cognitive and psychiatric disturbances.
    • This case underscores the importance of medication review in managing complex neurological and psychiatric conditions.