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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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Related Experiment Video

Updated: May 10, 2026

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
10:42

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Published on: August 10, 2016

Membrane separations for solid-liquid clarification within lignocellulosic biorefining processes.

Jennifer Leberknight1, Todd J Menkhaus

  • 1Dept. of Chemical and Biological Engineering, South Dakota School of Mines and Technology, Rapid City, SD, 57701.

Biotechnology Progress
|July 2, 2013
PubMed
Summary
This summary is machine-generated.

Selecting the right membrane material is key to reducing fouling in biorefineries. Optimal membranes for biomass hydrolysate clarification exhibit higher surface roughness, lower hydrophobicity, and neutral or positive charge for better performance.

Keywords:
biomassbiorefineryclarificationligninmicrofiltration

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Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids from Fermentation Broth Using Hollow-Fiber Membranes

Published on: August 9, 2024

Area of Science:

  • Biorefining
  • Membrane Science
  • Separation Technology

Background:

  • Membrane separations offer potential for water and energy savings in biorefineries.
  • Severe membrane fouling currently limits the widespread application of these technologies.
  • Biomass hydrolysate clarification is a critical step requiring efficient separation methods.

Purpose of the Study:

  • To establish a framework for selecting optimal membranes for solid-liquid clarification of biomass hydrolysate.
  • To correlate specific membrane properties with performance metrics to mitigate fouling.
  • To identify key membrane characteristics that enhance stability and separation efficiency.

Main Methods:

  • Evaluation of five distinct membrane materials (polyether sulfone, mixed cellulose esters, and three functionalized membranes).
  • Application of analytical characterizations and fouling models to assess membrane performance.
  • Correlation analysis between membrane properties (surface roughness, hydrophobicity, zeta potential, pore size) and key performance indicators (flux, fouling, separation factor).

Main Results:

  • Lignin was identified as the primary foulant, causing flux decline through physical entrapment and chemical adsorption.
  • Membranes with higher surface roughness, lower hydrophobicity, neutral/positive zeta potential, and smaller pores demonstrated superior performance.
  • Optimal membrane characteristics were linked to sustained high flux, reduced fouling, and high separation factors.

Conclusions:

  • The study provides a valuable framework for selecting membranes in biorefining applications.
  • Understanding the relationship between membrane properties and fouling is crucial for designing more stable and efficient separation materials.
  • These findings can guide the development of advanced membrane materials to improve biorefinery processes and reduce operational costs.