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Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection

Dan Wen1, Xin Du, Jian-Zeng Dong

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.

Heart (British Cardiac Society)
|July 2, 2013
PubMed

Insights

Elevated D-dimer and C-reactive protein (CRP) levels are key predictors of in-hospital death in patients with acute aortic dissection (AD). Type A AD also independently predicts mortality, highlighting these factors for risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers in Critical Care
  • Aortic Diseases

Background:

  • Acute aortic dissection (AD) is a life-threatening condition with significant in-hospital mortality.
  • Identifying reliable predictors of mortality is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To evaluate the predictive role of D-dimer and C-reactive protein (CRP) levels in determining in-hospital death among patients diagnosed with acute AD.
  • To assess the association of these biomarkers with mortality risk in acute aortic dissection.

Main Methods:

  • A single-center prospective study was conducted at a university hospital in China.
  • 114 patients diagnosed with acute AD were enrolled.
  • Admission levels of D-dimer and CRP were measured and analyzed for their association with in-hospital mortality.

Main Results:

  • Patients who died in-hospital exhibited significantly higher plasma D-dimer, CRP levels, and aortic diameter compared to survivors.
  • Plasma D-dimer concentrations were positively correlated with CRP levels and aortic diameter, and negatively with AD type and time from onset.
  • D-dimer (≥5.67 μg/mL) and CRP (≥11.21 mg/L) demonstrated high sensitivity and specificity in predicting in-hospital death.

Conclusions:

  • Elevated D-dimer and CRP levels, along with Type A acute AD, are independently associated with increased in-hospital mortality.
  • These biomarkers serve as important risk factors for predicting adverse outcomes in acute aortic dissection.
Abstract

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